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Lack of efficacy

Sometimes treatment does not have the intended effect. When this happens, the first thing to do is to check your diagnosis (autopsy, including sensitivity testing).

If a bacterial infection is not responding well to treatment while the lab report says that the micro-organism is sensitive to the active ingredient, it is important to check if the animals are getting the correct dose. Underdosing may occur when:

  1. The dose is not calculated correctly
    Always use a dose in mg or ml of product per kg body weight and the actual water intake of the animals as a starting point.
    Water intake is highly dependent on temperature, disease and feed composition (salt!), so assuming average water intake may lead to mistakes. If the animals drink less, they will obviously not get the full dose. If the animals drink more, the medicated water will be depleted too soon. Some animals will be overdosed while others will not get their full dose.
    Dechra offers a calculator to help avoid mistakes
    http://calculator.solustab.eu
     
  2. Pulse dosing is used
    Pulse dosing means supplying the daily dose in a shorter timeframe of for example 6 hours (i.e. at higher concentrations). There is a risk that in these 6 hours some animals will drink less than average, so they will not receive their full dose. More concentrated solutions can also affect the flavour, which will reduce water intake.
     
  3. The product does not dissolve or precipitates after dissolving initially

     
     
  4. The nipples are (partly) clogged

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